I essentially agree with what's already been said about Iolokus as an AU with a specific premise; while my personal view of the characters is quite different (though I must admit to having been very influenced since I read it), I can accept the grounds on which this story is built and let it run from there. This is not my Mulder and Scully, nor one I'd like to read about too often, but the overall vision is so compelling that I believe it. It certainly doesn't hurt that the writing just pops off the page- it manages to be at times gorgeously cinematic and yet fizzing with intellect and dry wit. Iolokus is probably why other first-person fics always fall flat for me.

As I said above I don't think I can re-read the lot at the moment to comment more specifically, but I do remember being bothered in a nitpicky way by Scully coming off an SSRI (for perfectly legitimate reasons) and apparently feeling no 'withdrawal' (antidepressants don't cause genuine withdrawal, but in my experience dropping them quickly brings you pretty close to the DTs) or indeed any worsening of symptoms. But I may be remembering a little wrong, and as I said, minor nitpick.